MAP3K12-binding inhibitory protein 1 (MBIP)

About MAP3K12-binding inhibitory protein 1

MAP3K12-binding inhibitory protein 1 (MBIP) is a protein from Homo sapiens identified by UniProt accession Q9NS73, 344 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	MAP3K12-binding inhibitory protein 1
UniProt accession	Q9NS73
Gene	MBIP
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.28
thyroid carcinoma · score 0.25
thyroid disease · score 0.25
self reported educational attainment · score 0.24
substance abuse · score 0.24
antisocial behaviour measurement · score 0.24
attention deficit hyperactivity disorder · score 0.24
breast adenocarcinoma · score 0.22
differentiated thyroid carcinoma · score 0.19
thyroid stimulating hormone measurement · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS73-F1	alphafold	PREDICTED	68.42	—

Amino-acid sequence (344 residues)

MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV VKITIDWNKL QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA VEEIGRTEMG NKNEVNDKFS IGDLQEEEKH KESDLRDVKK TQIHFDPEVV QIKAGKAEID RRISAFIERK QAEINENNVR EFCNVIDCNQ ENSCARTDAI FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML RDCGNQAVEE RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSFSG KRRKVQPPQQ NYSLAELDEK ISALKQALLR KSREAESMAT HHLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards