LanC-like protein 2 (LANCL2)

About LanC-like protein 2

LanC-like protein 2 (LANCL2) is a protein from Homo sapiens identified by UniProt accession Q9NS86, 450 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	LanC-like protein 2
UniProt accession	Q9NS86
Gene	LANCL2
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

respiratory tract infectious disorder · score 0.30
glioblastoma · score 0.08
lung adenocarcinoma · score 0.07
glioblastoma multiforme · score 0.07
neoplasm · score 0.07
X-linked severe congenital neutropenia · score 0.06
Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency · score 0.05
common variable immunodeficiency · score 0.05
isolated agammaglobulinemia · score 0.05
combined immunodeficiency with skin granulomas · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS86-F1	alphafold	PREDICTED	91.99	—

Amino-acid sequence (450 residues)

MGETMSKRLK LHLGGEAEME ERAFVNPFPD YEAAAGALLA SGAAEETGCV RPPATTDEPG LPFHQDGKII HNFIRRIQTK IKDLLQQMEE GLKTADPHDC SAYTGWTGIA LLYLQLYRVT CDQTYLLRSL DYVKRTLRNL NGRRVTFLCG DAGPLAVGAV IYHKLRSDCE SQECVTKLLQ LQRSVVCQES DLPDELLYGR AGYLYALLYL NTEIGPGTVC ESAIKEVVNA IIESGKTLSR EERKTERCPL LYQWHRKQYV GAAHGMAGIY YMLMQPAAKV DQETLTEMVK PSIDYVRHKK FRSGNYPSSL SNETDRLVHW CHGAPGVIHM LMQAYKVFKE EKYLKEAMEC SDVIWQRGLL RKGYGICHGT AGNGYSFLSL YRLTQDKKYL YRACKFAEWC LDYGAHGCRI PDRPYSLFEG MAGAIHFLSD VLGPETSRFP AFELDSSKRD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards