E3 ubiquitin-protein ligase RAD18 (RAD18)

About E3 ubiquitin-protein ligase RAD18

E3 ubiquitin-protein ligase RAD18 (RAD18) is a protein from Homo sapiens identified by UniProt accession Q9NS91, 495 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RAD18
UniProt accession	Q9NS91
Gene	RAD18
Organism	Homo sapiens
Length	495 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
body height · score 0.30
vital capacity · score 0.27
age at menopause · score 0.27
lysosomal storage disease · score 0.26
uterine fibroid · score 0.21
breast adenocarcinoma · score 0.18
neoplasm · score 0.10
metabolite measurement · score 0.10
cancer · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS91-F1	alphafold	PREDICTED	67.00	—

Amino-acid sequence (495 residues)

MDSLAESRWP PGLAVMKTID DLLRCGICFE YFNIAMIIPQ CSHNYCSLCI RKFLSYKTQC PTCCVTVTEP DLKNNRILDE LVKSLNFARN HLLQFALESP AKSPASSSSK NLAVKVYTPV ASRQSLKQGS RLMDNFLIRE MSGSTSELLI KENKSKFSPQ KEASPAAKTK ETRSVEEIAP DPSEAKRPEP PSTSTLKQVT KVDCPVCGVN IPESHINKHL DSCLSREEKK ESLRSSVHKR KPLPKTVYNL LSDRDLKKKL KEHGLSIQGN KQQLIKRHQE FVHMYNAQCD ALHPKSAAEI VREIENIEKT RMRLEASKLN ESVMVFTKDQ TEKEIDEIHS KYRKKHKSEF QLLVDQARKG YKKIAGMSQK TVTITKEDES TEKLSSVCMG QEDNMTSVTN HFSQSKLDSP EELEPDREED SSSCIDIQEV LSSSESDSCN SSSSDIIRDL LEEEEAWEAS HKNDLQDTEI SPRQNRRTRA AESAEIEPRN KRNRN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards