About Transmembrane 7 superfamily member 3
Transmembrane 7 superfamily member 3 (TM7SF3) is a protein
from Homo sapiens identified by UniProt accession
Q9NS93, 570 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Transmembrane 7 superfamily member 3 |
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| UniProt accession | Q9NS93 |
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| Gene | TM7SF3 |
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| Organism | Homo sapiens |
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| Length | 570 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- basophil percentage of leukocytes · score 0.22
- mean platelet volume · score 0.20
- basophil count · score 0.09
- systolic blood pressure · score 0.03
- neutrophil count · score 0.02
- self reported educational attainment · score 0.02
- Hepatic fibrosis · score 0.02
- mathematical ability · score 0.02
- myeloid white cell count · score 0.02
- adolescent idiopathic scoliosis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NS93-F1 | alphafold | PREDICTED | 88.38 | — |
Amino-acid sequence (570 residues)
MGFLQLLVVA VLASEHRVAG AAEVFGNSSE GLIEFSVGKF RYFELNRPFP EEAILHDISS NVTFLIFQIH SQYQNTTVSF SPTLLSNSSE TGTASGLVFI LRPEQSTCTW YLGTSGIQPV QNMAILLSYS ERDPVPGGCN LEFDLDIDPN IYLEYNFFET TIKFAPANLG YARGVDPPPC DAGTDQDSRW RLQYDVYQYF LPENDLTEEM LLKHLQRMVS VPQVKASALK VVTLTANDKT SVSFSSLPGQ GVIYNVIVWD PFLNTSAAYI PAHTYACSFE AGEGSCASLG RVSSKVFFTL FALLGFFICF FGHRFWKTEL FFIGFIIMGF FFYILITRLT PIKYDVNLIL TAVTGSVGGM FLVAVWWRFG ILSICMLCVG LVLGFLISSV TFFTPLGNLK IFHDDGVFWV TFSCIAILIP VVFMGCLRIL NILTCGVIGS YSVVLAIDSY WSTSLSYITL NVLKRALNKD FHRAFTNVPF QTNDFIILAV WGMLAVSGIT LQIRRERGRP FFPPHPYKLW KQERERRVTN ILDPSYHIPP LRERLYGRLT QIKGLFQKEQ PAGERTPLLL
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