About Semaphorin-3G
Semaphorin-3G (SEMA3G) is a protein
from Homo sapiens identified by UniProt accession
Q9NS98, 782 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Semaphorin-3G |
|---|
| UniProt accession | Q9NS98 |
|---|
| Gene | SEMA3G |
|---|
| Organism | Homo sapiens |
|---|
| Length | 782 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.21
- blood protein measurement · score 0.21
- apolipoprotein A 1 measurement · score 0.17
- high density lipoprotein cholesterol measurement · score 0.14
- calcium measurement · score 0.11
- eosinophil count · score 0.10
- chronotype measurement · score 0.08
- waist-hip ratio · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
- neoplasm · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NS98-F1 | alphafold | PREDICTED | 82.80 | — |
Amino-acid sequence (782 residues)
MAPSAWAICW LLGGLLLHGG SSGPSPGPSV PRLRLSYRDL LSANRSAIFL GPQGSLNLQA MYLDEYRDRL FLGGLDALYS LRLDQAWPDP REVLWPPQPG QREECVRKGR DPLTECANFV RVLQPHNRTH LLACGTGAFQ PTCALITVGH RGEHVLHLEP GSVESGRGRC PHEPSRPFAS TFIDGELYTG LTADFLGREA MIFRSGGPRP ALRSDSDQSL LHDPRFVMAA RIPENSDQDN DKVYFFFSET VPSPDGGSNH VTVSRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMADIW EVFNGPFAHR DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY PDEVLQFARA HPLMFWPVRP RHGRPVLVKT HLAQQLHQIV VDRVEAEDGT YDVIFLGTDS GSVLKVIALQ AGGSAEPEEV VLEELQVFKV PTPITEMEIS VKRQMLYVGS RLGVAQLRLH QCETYGTACA ECCLARDPYC AWDGASCTHY RPSLGKRRFR RQDIRHGNPA LQCLGQSQEE EAVGLVAATM VYGTEHNSTF LECLPKSPQA AVRWLLQRPG DEGPDQVKTD ERVLHTERGL LFRRLSRFDA GTYTCTTLEH GFSQTVVRLA LVVIVASQLD NLFPPEPKPE EPPARGGLAS TPPKAWYKDI LQLIGFANLP RVDEYCERVW CRGTTECSGC FRSRSRGKQA RGKSWAGLEL GKKMKSRVHA EHNRTPREVE AT
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