About Fibroblast growth factor 21
Fibroblast growth factor 21 (FGF21) is a protein
from Homo sapiens identified by UniProt accession
Q9NSA1, 209 residues long.
MolForge cross-references it against 0 known binders and
601 disease associations.
Target properties
| Protein name | Fibroblast growth factor 21 |
|---|
| UniProt accession | Q9NSA1 |
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| Gene | FGF21 |
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| Organism | Homo sapiens |
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| Length | 209 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (601)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.35
- diet measurement · score 0.34
- energy intake · score 0.33
- cystatin C measurement · score 0.29
- serum urea measurement · score 0.28
- sodium measurement · score 0.24
- Abnormal urine sodium concentration · score 0.24
- aspartate aminotransferase measurement · score 0.24
- blood urea nitrogen measurement · score 0.24
- IGF-1 measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NSA1-F1 | alphafold | PREDICTED | 76.77 | — |
Amino-acid sequence (209 residues)
MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY TDDAQQTEAH LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR FLCQRPDGAL YGSLHFDPEA CSFRELLLED GYNVYQSEAH GLPLHLPGNK SPHRDPAPRG PARFLPLPGL PPALPEPPGI LAPQPPDVGS SDPLSMVGPS QGRSPSYAS
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