Homer protein homolog 3 (HOMER3)

About Homer protein homolog 3

Homer protein homolog 3 (HOMER3) is a protein from Homo sapiens identified by UniProt accession Q9NSC5, 361 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Homer protein homolog 3
UniProt accession	Q9NSC5
Gene	HOMER3
Organism	Homo sapiens
Length	361 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin · score 0.24
hepatocellular carcinoma · score 0.09
neoplasm · score 0.08
triple-negative breast cancer · score 0.07
non-small cell lung carcinoma · score 0.05
cancer · score 0.04
urinary bladder carcinoma · score 0.02
coronary artery disease · score 0.02
Cirrhosis · score 0.02
hepatitis B virus infection · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NSC5-F1	alphafold	PREDICTED	82.34	—

Amino-acid sequence (361 residues)

MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQHLT QFAEKFQEVK EAARLAREKS QDGGELTSPA LGLASHQVPP SPLVSANGPG EEKLFRSQSA DAPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNNKLA GALREANAAA AQWRQQLEAQ RAEAERLRQR VAELEAQAAS EVTPTGEKEG LGQGQSLEQL EALVQTKDQE IQTLKSQTGG PREALEAAER EETQQKVQDL ETRNAELEHQ LRAMERSLEE ARAERERARA EVGRAAQLLD VSLFELSELR EGLARLAEAA P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards