About Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1) is a protein
from Homo sapiens identified by UniProt accession
Q9NSC7, 600 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
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| UniProt accession | Q9NSC7 |
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| Gene | ST6GALNAC1 |
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| Organism | Homo sapiens |
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| Length | 600 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.13
- neutrophil percentage of leukocytes · score 0.11
- Lynch syndrome · score 0.06
- inflammatory bowel disease · score 0.06
- neoplasm · score 0.06
- Hirschsprung disease · score 0.06
- Autosomal recessive early-onset inflammatory bowel disease · score 0.06
- lung adenocarcinoma · score 0.05
- colorectal cancer, susceptibility to, 3 · score 0.05
- AXIN2-related attenuated familial adenomatous polyposis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NSC7-F1 | alphafold | PREDICTED | 72.41 | — |
Amino-acid sequence (600 residues)
MRSCLWRCRH LSQGVQWSLL LAVLVFFLFA LPSFIKEPQT KPSRHQRTEN IKERSLQSLA KPKSQAPTRA RRTTIYAEPV PENNALNTQT QPKAHTTGDR GKEANQAPPE EQDKVPHTAQ RAAWKSPEKE KTMVNTLSPR GQDAGMASGR TEAQSWKSQD TKTTQGNGGQ TRKLTASRTV SEKHQGKAAT TAKTLIPKSQ HRMLAPTGAV STRTRQKGVT TAVIPPKEKK PQATPPPAPF QSPTTQRNQR LKAANFKSEP RWDFEEKYSF EIGGLQTTCP DSVKIKASKS LWLQKLFLPN LTLFLDSRHF NQSEWDRLEH FAPPFGFMEL NYSLVQKVVT RFPPVPQQQL LLASLPAGSL RCITCAVVGN GGILNNSHMG QEIDSHDYVF RLSGALIKGY EQDVGTRTSF YGFTAFSLTQ SLLILGNRGF KNVPLGKDVR YLHFLEGTRD YEWLEALLMN QTVMSKNLFW FRHRPQEAFR EALHMDRYLL LHPDFLRYMK NRFLRSKTLD GAHWRIYRPT TGALLLLTAL QLCDQVSAYG FITEGHERFS DHYYDTSWKR LIFYINHDFK LEREVWKRLH DEGIIRLYQR PGPGTAKAKN
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