About Cytokine-inducible SH2-containing protein
Cytokine-inducible SH2-containing protein (CISH) is a protein
from Homo sapiens identified by UniProt accession
Q9NSE2, 258 residues long.
MolForge cross-references it against 0 known binders and
425 disease associations.
Target properties
| Protein name | Cytokine-inducible SH2-containing protein |
|---|
| UniProt accession | Q9NSE2 |
|---|
| Gene | CISH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 258 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (425)
Diseases linked to this target (Open Targets).
- eosinophil percentage of leukocytes · score 0.28
- eosinophil count · score 0.22
- appendicular lean mass · score 0.11
- whole body water mass · score 0.09
- infection · score 0.08
- infect · score 0.08
- schizophrenia · score 0.06
- neoplasm · score 0.06
- forced expiratory volume · score 0.06
- C-reactive protein measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NSE2-F1 | alphafold | PREDICTED | 72.78 | — |
Amino-acid sequence (258 residues)
MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCTAD TRSDSPDPAP TPALPMPKED APSDPALPAP PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC LPLPRRMADY LRQYPFQL
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