Centromere protein M (CENPM)

About Centromere protein M

Centromere protein M (CENPM) is a protein from Homo sapiens identified by UniProt accession Q9NSP4, 180 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Centromere protein M
UniProt accession	Q9NSP4
Gene	CENPM
Organism	Homo sapiens
Length	180 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.24
hepatocellular carcinoma · score 0.10
breast cancer · score 0.10
lung adenocarcinoma · score 0.10
sex hormone-binding globulin measurement · score 0.09
diet measurement · score 0.09
cancer · score 0.08
nonpapillary renal cell carcinoma · score 0.08
pancreatic neoplasm · score 0.07
neoplasm · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NSP4-F1	alphafold	PREDICTED	89.20	—

Amino-acid sequence (180 residues)

MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK SLPLPSSVNR PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL ATGAGRESHC SIHRHTVVKL AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL QICAGHVPGV SALNLLSLLR SSEGPSLEDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards