About 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) is a protein
from Homo sapiens identified by UniProt accession
Q9NST1, 481 residues long.
MolForge cross-references it against 0 known binders and
222 disease associations.
Target properties
| Protein name | 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 |
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| UniProt accession | Q9NST1 |
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| Gene | PNPLA3 |
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| Organism | Homo sapiens |
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| Length | 481 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (222)
Diseases linked to this target (Open Targets).
- non-alcoholic fatty liver disease · score 0.69
- serum alanine aminotransferase measurement · score 0.50
- cirrhosis of liver · score 0.49
- aspartate aminotransferase measurement · score 0.49
- platelet count · score 0.49
- type 2 diabetes mellitus · score 0.48
- mean corpuscular volume · score 0.48
- urate measurement · score 0.48
- hemoglobin measurement · score 0.48
- mean corpuscular hemoglobin · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NST1-F1 | alphafold | PREDICTED | 71.44 | — |
Amino-acid sequence (481 residues)
MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSGI PLEQTLQVLS DLVRKARSRN IGIFHPSFNL SKFLRQGLCK CLPANVHQLI SGKIGISLTR VSDGENVLVS DFRSKDEVVD ALVCSCFIPF YSGLIPPSFR GVRYVDGGVS DNVPFIDAKT TITVSPFYGE YDICPKVKST NFLHVDITKL SLRLCTGNLY LLSRAFVPPD LKVLGEICLR GYLDAFRFLE EKGICNRPQP GLKSSSEGMD PEVAMPSWAN MSLDSSPESA ALAVRLEGDE LLDHLRLSIL PWDESILDTL SPRLATALSE EMKDKGGYMS KICNLLPIRI MSYVMLPCTL PVESAIAIVQ RLVTWLPDMP DDVLWLQWVT SQVFTRVLMC LLPASRSQMP VSSQQASPCT PEQDWPCWTP CSPKGCPAET KAEATPRSIL RSSLNFFLGN KVPAGAEGLS TFPSFSLEKS L
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