About Leucine-rich repeat-containing protein 4B
Leucine-rich repeat-containing protein 4B (LRRC4B) is a protein
from Homo sapiens identified by UniProt accession
Q9NT99, 713 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 4B |
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| UniProt accession | Q9NT99 |
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| Gene | LRRC4B |
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| Organism | Homo sapiens |
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| Length | 713 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- visual perception measurement · score 0.13
- Autosomal dominant striatal neurodegeneration · score 0.04
- Landau-Kleffner syndrome · score 0.04
- Cortical dysplasia - focal epilepsy syndrome · score 0.04
- developmental and epileptic encephalopathy, 43 · score 0.04
- Lennox-Gastaut syndrome · score 0.03
- X-linked dominant intellectual disability - epilepsy syndrome · score 0.03
- developmental and epileptic encephalopathy 104 · score 0.03
- late infantile neuronal ceroid lipofuscinosis · score 0.03
- cortical dysplasia-focal epilepsy syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NT99-F1 | alphafold | PREDICTED | 71.70 | — |
Amino-acid sequence (713 residues)
MARARGSPCP PLPPGRMSWP HGALLFLWLF SPPLGAGGGG VAVTSAAGGG SPPATSCPVA CSCSNQASRV ICTRRDLAEV PASIPVNTRY LNLQENGIQV IRTDTFKHLR HLEILQLSKN LVRKIEVGAF NGLPSLNTLE LFDNRLTTVP TQAFEYLSKL RELWLRNNPI ESIPSYAFNR VPSLRRLDLG ELKRLEYISE AAFEGLVNLR YLNLGMCNLK DIPNLTALVR LEELELSGNR LDLIRPGSFQ GLTSLRKLWL MHAQVATIER NAFDDLKSLE ELNLSHNNLM SLPHDLFTPL HRLERVHLNH NPWHCNCDVL WLSWWLKETV PSNTTCCARC HAPAGLKGRY IGELDQSHFT CYAPVIVEPP TDLNVTEGMA AELKCRTGTS MTSVNWLTPN GTLMTHGSYR VRISVLHDGT LNFTNVTVQD TGQYTCMVTN SAGNTTASAT LNVSAVDPVA AGGTGSGGGG PGGSGGVGGG SGGYTYFTTV TVETLETQPG EEALQPRGTE KEPPGPTTDG VWGGGRPGDA AGPASSSTTA PAPRSSRPTE KAFTVPITDV TENALKDLDD VMKTTKIIIG CFVAITFMAA VMLVAFYKLR KQHQLHKHHG PTRTVEIINV EDELPAASAV SVAAAAAVAS GGGVGGDSHL ALPALERDHL NHHHYVAAAF KAHYSSNPSG GGCGGKGPPG LNSIHEPLLF KSGSKENVQE TQI
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