About Polycystin family receptor for egg jelly
Polycystin family receptor for egg jelly (PKDREJ) is a protein
from Homo sapiens identified by UniProt accession
Q9NTG1, 2253 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Polycystin family receptor for egg jelly |
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| UniProt accession | Q9NTG1 |
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| Gene | PKDREJ |
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| Organism | Homo sapiens |
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| Length | 2253 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.26
- testosterone measurement · score 0.26
- low density lipoprotein cholesterol measurement · score 0.25
- triglyceride measurement · score 0.21
- fat body mass · score 0.15
- body weight · score 0.14
- metabolite measurement · score 0.12
- hip circumference · score 0.10
- azoospermia · score 0.06
- spermatogenic failure 59 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NTG1-F1 | alphafold | PREDICTED | 70.72 | — |
Amino-acid sequence (2253 residues)
MRPGPALLLL GVGLSLSVGR LPLPPVPRGA QAAVSGAPGG LLRGAPGLGV RGGRALLSLR PSAVRAGGAV LSGRGSLCFP HGGTGRRWYC LDLRVLLSAQ RLPWPAAPAL ALVDLQLSAR GGRLSLTWSV RLPRSPGRLA WAFRLRLLGP GAARPASPAA RVSPRSAAPG PRPQQGFVAR TECPTDGPAR VMLQAVNSSS HRAVESSVSC QINACVIQRV RINTDQKGAP VRLSMQAEAT INASVQLDCP AARAIAQYWQ VFSVPAVGQA PDWTQPLDLP QLEIRNSPLF IHIPNNSLQW GVYVFNFTVS ITTGNPKMPE VKDSDAVYVW IVRSSLQAVM LGDANITANF TEQLILDGST SSDPDADSPL QGLQFFWYCT TDPRNYGGDR IILGSKEVCH PEQANLKWPW ASGPVLTLLP ETLKGDHVYF FRMVIRKDSR TAFSDKRVHV LQGPKAIAHI TCIENCERNF IVSDRFSLFL NCTNCASRDF YKWSILSSSG GEMLFDWMGE TVTGRNGAYL SIKAFAFRHF LEAEFSISLY LACWSGVTSV FRHSFIINHG PQIGECKINP AKGIALITKF VVQCSNFRDK HVPLTYKIIV SDLHSVGEIS SVKENTLGTI LYLGPQSTVP PSFLPVGMLA SQYGLKIYAQ VYDSLGAFSQ VTLHATAQAP TDKNSSKTVL NQLLSFTVGP SSLLSTLIQK KDFLPAGYLL YIVASVLNNM KTELPLRDDR VNLRKHLIDQ SFLLPVSTLV EIGQVVMTIT KLTQKPSEFT WDAQKRATMR VWQANQALQE YQQKDKRFRS EQIEIVSTGI LMSLSNILKM TSPHQVVKDP FYVIESLSDT ILANKVPGNK TTSMRTPNFN MYVKKVEKWG INQLFRNEKH CRNCFYPTLN VSSVPGLSAN GPISTMFCDF TNDLFPWLND QENTSVEVSG FRMTGVADNG SVLEITPDVA EVYLVRKNLT FAAFNLTVGP NSEVDGSLKK TTGGFSFQVD STVLREVLVH IVTEVMVLFT VLVYTGSQIT PTALVATFLV PHDIPPFASQ SALFDPACTV KKARVVCLPV SLLQLIAQHS HSPHCTVSIV LQAPRFVMKL NDKLVRISIF SVQCLDMYGI QSEWREGYCI LGEKTSWYEV HCICKNVVRA RRQLGTIGLT GIHLHTHYVM AKVIVIPNPV DLRLNIIKSL HQNPVTLFTV LFIILLYVGL AFWALYRDEM DQHLRGHVIV LPDNDPYDNL CYLVTIFTGS RWGSGTRANV FVQLRGTVST SDVHCLSHPH FTTLYRGSIN TFLLTTKSDL GDIHSIRVWH NNEGRSPSWY LSRIKVENLF SRHIWLFICQ KWLSVDTTLD RTFHVTHPDE RLTRKDFFFI DVSSNLRKNH MWFSIFASVV AKTFNRLQRL SCCLAMLLSS LLCNIMFFNL NRQEQTESRE RKYMRSMMIG IESVLITIPV QLLITFLFTC SQRKPQADLK EVSPQKHPLM SEASEHWEEY LRKWHAYETA KVHPREVAKP ASKGKPRLPK ASPKATSKPK HRHRKAQIKT PETLGPNTNS NNNIEDDQDV HSEQHPSQKD LQQLKKKPRI VLPWWCVYVA WFLVFATSSI SSFFIVFYGL TYGYDKSIEW LFASFCSFCQ SVLLVQPSKI ILLSGFRTNK PKYCKNLSWS TKYKYTEIRL DGMRMHPEEM QRIHDQIVRI RGTRMYQPLT EDEIRIFKRK KRIKRRALLF LSYILTHFIF LALLLILIVL LRHTDCFYYN QFIRDRFSMD LATVTKLEDI YRWLNSVLLP LLHNDLNPTF LPESSSKILG LPLMRQVRAK SSEKMCLPAE KFVQNSIRRE IHCHPKYGID PEDTKNYSGF WNEVDKQAID ESTNGFTYKP QGTQWLYYSY GLLHTYGSGG YALYFFPEQQ RFNSTLRLKE LQESNWLDEK TWAVVLELTT FNPDINLFCS ISVIFEVSQL GVVNTSISLH SFSLADFDRK ASAEIYLYVA ILIFFLAYVV DEGCIIMQER ASYVRSVYNL LNFALKCIFT VLIVLFLRKH FLATGIIRFY LSNPEDFIPF HAVSQVDHIM RIILGFLLFL TILKTLRYSR FFYDVRLAQR AIQAALPGIC HMAFVVSVYF FVYMAFGYLV FGQHEWNYSN LIHSTQTVFS YCVSAFQNTE FSNNRILGVL FLSSFMLVMI CVLINLFQAV ILSAYEEMKQ PVYEEPSDEV EAMTYLCRKL RTMFSFLTSQ SKAKDEPEFF IDMLYGQPEK NSHRYLGLKT RNINGKKMVY LVV
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