About Acetyl-coenzyme A synthetase 2-like, mitochondrial
Acetyl-coenzyme A synthetase 2-like, mitochondrial (ACSS1) is a protein
from Homo sapiens identified by UniProt accession
Q9NUB1, 689 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Acetyl-coenzyme A synthetase 2-like, mitochondrial |
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| UniProt accession | Q9NUB1 |
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| Gene | ACSS1 |
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| Organism | Homo sapiens |
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| Length | 689 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- acetate measurement · score 0.52
- alcohol consumption measurement · score 0.39
- blood protein measurement · score 0.37
- platelet count · score 0.30
- neurodegenerative disease · score 0.22
- lean body mass · score 0.21
- cutaneous melanoma · score 0.12
- haptoglobin measurement · score 0.09
- body weight · score 0.07
- body mass index · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NUB1-F1 | alphafold | PREDICTED | 87.13 | — |
Amino-acid sequence (689 residues)
MAARTLGRGV GRLLGSLRGL SGQPARPPCG VSAPRRAASG PSGSAPAVAA AAAQPGSYPA LSAQAAREPA AFWGPLARDT LVWDTPYHTV WDCDFSTGKI GWFLGGQLNV SVNCLDQHVR KSPESVALIW ERDEPGTEVR ITYRELLETT CRLANTLKRH GVHRGDRVAI YMPVSPLAVA AMLACARIGA VHTVIFAGFS AESLAGRIND AKCKVVITFN QGLRGGRVVE LKKIVDEAVK HCPTVQHVLV AHRTDNKVHM GDLDVPLEQE MAKEDPVCAP ESMGSEDMLF MLYTSGSTGM PKGIVHTQAG YLLYAALTHK LVFDHQPGDI FGCVADIGWI TGHSYVVYGP LCNGATSVLF ESTPVYPNAG RYWETVERLK INQFYGAPTA VRLLLKYGDA WVKKYDRSSL RTLGSVGEPI NCEAWEWLHR VVGDSRCTLV DTWWQTETGG ICIAPRPSEE GAEILPAMAM RPFFGIVPVL MDEKGSVVEG SNVSGALCIS QAWPGMARTI YGDHQRFVDA YFKAYPGYYF TGDGAYRTEG GYYQITGRMD DVINISGHRL GTAEIEDAIA DHPAVPESAV IGYPHDIKGE AAFAFIVVKD SAGDSDVVVQ ELKSMVATKI AKYAVPDEIL VVKRLPKTRS GKVMRRLLRK IITSEAQELG DTTTLEDPSI IAEILSVYQK CKDKQAAAK
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