Zinc finger CCHC domain-containing protein 3 (ZCCHC3)

About Zinc finger CCHC domain-containing protein 3

Zinc finger CCHC domain-containing protein 3 (ZCCHC3) is a protein from Homo sapiens identified by UniProt accession Q9NUD5, 403 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Zinc finger CCHC domain-containing protein 3
UniProt accession	Q9NUD5
Gene	ZCCHC3
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

plasma fibronectin deficiency · score 0.06
Crigler-Najjar syndrome type 2 · score 0.06
transient familial neonatal hyperbilirubinemia · score 0.05
gluthathione peroxidase deficiency · score 0.04
Rotor syndrome · score 0.04
Dubin-Johnson syndrome · score 0.04
Hereditary persistence of alpha-fetoprotein · score 0.04
hypercholanemia, familial, 2 · score 0.04
hemolytic anemia due to glutathione reductase deficiency · score 0.04
congenital lethal erythroderma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NUD5-F1	alphafold	PREDICTED	65.72	—

Amino-acid sequence (403 residues)

MATGGGAEEE RKRGRPQLLP PARPAARGEE ADGGREKMGW AQVVKNLAEK KGEFREPRPP RREEESGGGG GSAGLGGPAG LAAPDLGDFP PAGRGDPKGR RRDPAGEAVD PRKKKGAAEA GRRKKAEAAA AAMATPARPG EAEDAAERPL QDEPAAAAGP GKGRFLVRIC FQGDEGACPT RDFVVGALIL RSIGMDPSDI YAVIQIPGSR EFDVSFRSAE KLALFLRVYE EKREQEDCWE NFVVLGRSKS SLKTLFILFR NETVDVEDIV TWLKRHCDVL AVPVKVTDRF GIWTGEYKCE IELRQGEGGV RHLPGAFFLG AERGYSWYKG QPKTCFKCGS RTHMSGSCTQ DRCFRCGEEG HLSPYCRKGI VCNLCGKRGH AFAQCPKAVH NSVAAQLTGV AGH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards