About GPI alpha-1,6-mannosyltransferase 2
GPI alpha-1,6-mannosyltransferase 2 (PIGV) is a protein
from Homo sapiens identified by UniProt accession
Q9NUD9, 493 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | GPI alpha-1,6-mannosyltransferase 2 |
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| UniProt accession | Q9NUD9 |
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| Gene | PIGV |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (135)
Diseases linked to this target (Open Targets).
- hyperphosphatasia-intellectual disability syndrome · score 0.68
- genetic disorder · score 0.45
- Elevated circulating alkaline phosphatase concentration · score 0.26
- membrane-bound aminopeptidase P measurement · score 0.10
- urate measurement · score 0.09
- high density lipoprotein cholesterol measurement · score 0.09
- apolipoprotein A 1 measurement · score 0.09
- vitamin D measurement · score 0.09
- sex hormone-binding globulin measurement · score 0.09
- serum alanine aminotransferase measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NUD9-F1 | alphafold | PREDICTED | 90.21 | — |
Amino-acid sequence (493 residues)
MWPQDPSRKE VLRFAVSCRI LTLMLQALFN AIIPDHHAEA FSPPRLAPSG FVDQLVEGLL GGLSHWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLVGTE LLRPLRGLLS LRSCLLISVA SLNFLFFMLA AVALHDLGCL VLHCPHQSFY AALLFCLSPA NVFLAAGYSE ALFALLTFSA MGQLERGRVW TSVLLFAFAT GVRSNGLVSV GFLMHSQCQG FFSSLTMLNP LRQLFKLMAS LFLSVFTLGL PFALFQYYAY TQFCLPGSAR PIPEPLVQLA VDKGYRIAEG NEPPWCFWDV PLIYSYIQDV YWNVGFLKYY ELKQVPNFLL AAPVAILVAW ATWTYVTTHP WLCLTLGLQR SKNNKTLEKP DLGFLSPQVF VYVVHAAVLL LFGGLCMHVQ VLTRFLGSST PIMYWFPAHL LQDQEPLLRS LKTVPWKPLA EDSPPGQKVP RNPIMGLLYH WKTCSPVTRY ILGYFLTYWL LGLLLHCNFL PWT
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