Muscleblind-like protein 3 (MBNL3)

About Muscleblind-like protein 3

Muscleblind-like protein 3 (MBNL3) is a protein from Homo sapiens identified by UniProt accession Q9NUK0, 354 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Muscleblind-like protein 3
UniProt accession	Q9NUK0
Gene	MBNL3
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.08
alkaline phosphatase measurement · score 0.06
Distal myopathy, Nonaka type · score 0.06
exercise intolerance, riboflavin-responsive · score 0.06
autosomal dominant distal myopathy · score 0.05
inclusion body myositis · score 0.05
GNE myopathy · score 0.05
myopathy · score 0.05
tibial muscular dystrophy · score 0.05
tubular aggregate myopathy · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NUK0-F1	alphafold	PREDICTED	67.41	—

Amino-acid sequence (354 residues)

MTAVNVALIR DTKWLTLEVC REFQRGTCSR ADADCKFAHP PRVCHVENGR VVACFDSLKG RCTRENCKYL HPPPHLKTQL EINGRNNLIQ QKTAAAMFAQ QMQLMLQNAQ MSSLGSFPMT PSIPANPPMA FNPYIPHPGM GLVPAELVPN TPVLIPGNPP LAMPGAVGPK LMRSDKLEVC REFQRGNCTR GENDCRYAHP TDASMIEASD NTVTICMDYI KGRCSREKCK YFHPPAHLQA RLKAAHHQMN HSAASAMALQ PGTLQLIPKR SALEKPNGAT PVFNPTVFHC QQALTNLQLP QPAFIPAGPI LCMAPASNIV PMMHGATPTT VSAATTPATS VPFAAPTTGN QLKF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards