Transmembrane protein 106B (TMEM106B)

About Transmembrane protein 106B

Transmembrane protein 106B (TMEM106B) is a protein from Homo sapiens identified by UniProt accession Q9NUM4, 274 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.

Target properties

Protein name	Transmembrane protein 106B
UniProt accession	Q9NUM4
Gene	TMEM106B
Organism	Homo sapiens
Length	274 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (140)

Diseases linked to this target (Open Targets).

tremor-ataxia-central hypomyelination syndrome · score 0.63
unipolar depression · score 0.46
neuroticism measurement · score 0.43
alkaline phosphatase measurement · score 0.42
coronary artery disease · score 0.40
high density lipoprotein cholesterol measurement · score 0.40
depressive symptom measurement · score 0.39
frontotemporal dementia · score 0.37
frontotemporal dementia and/or amyotrophic lateral sclerosis 1 · score 0.37
GRN-related frontotemporal lobar degeneration with Tdp43 inclusions · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NUM4-F1	alphafold	PREDICTED	75.86	—

Amino-acid sequence (274 residues)

MGKSLSHLPL HSSKEDAYDG VTSENMRNGL VNSEVHNEDG RNGDVSQFPY VEFTGRDSVT CPTCQGTGRI PRGQENQLVA LIPYSDQRLR PRRTKLYVMA SVFVCLLLSG LAVFFLFPRS IDVKYIGVKS AYVSYDVQKR TIYLNITNTL NITNNNYYSV EVENITAQVQ FSKTVIGKAR LNNITIIGPL DMKQIDYTVP TVIAEEMSYM YDFCTLISIK VHNIVLMMQV TVTTTYFGHS EQISQERYQY VDCGRNTTYQ LGQSEYLNVL QPQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards