About Biogenesis of lysosome-related organelles complex 1 subunit 4
Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC1S4) is a protein
from Homo sapiens identified by UniProt accession
Q9NUP1, 217 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Biogenesis of lysosome-related organelles complex 1 subunit 4 |
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| UniProt accession | Q9NUP1 |
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| Gene | BLOC1S4 |
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| Organism | Homo sapiens |
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| Length | 217 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.20
- mean platelet volume · score 0.12
- Hermansky-Pudlak syndrome · score 0.05
- Hermansky-Pudlak syndrome without pulmonary fibrosis · score 0.04
- Glanzmann thrombasthenia 1 · score 0.04
- Hermansky-Pudlak syndrome 9 · score 0.04
- Hermansky-Pudlak syndrome 7 · score 0.04
- Hermansky-Pudlak syndrome 11 · score 0.04
- uncombable hair syndrome · score 0.04
- Hermansky-Pudlak syndrome 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NUP1-F1 | alphafold | PREDICTED | 72.78 | — |
Amino-acid sequence (217 residues)
MEGSFSDGGA LPEGLAEEAE PQGAAWSGDS GTVSQSHSSA SGPWEDEGAE DGAPGRDLPL LRRAAAGYAA CLLPGAGARP EVEALDASLE DLLTRVDEFV GMLDMLRGDS SHVVSEGVPR IHAKAAEMRR IYSRIDRLEA FVRMVGGRVA RMEEQVTKAE AELGTFPRAF KKLLHTMNVP SLFSKSAPSR PQQAGYEAPV LFRTEDYFPC CSERPQL
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