AP-5 complex subunit sigma-1 (AP5S1)

About AP-5 complex subunit sigma-1

AP-5 complex subunit sigma-1 (AP5S1) is a protein from Homo sapiens identified by UniProt accession Q9NUS5, 200 residues long. MolForge cross-references it against 0 known binders and 6 disease associations.

Target properties

Protein name	AP-5 complex subunit sigma-1
UniProt accession	Q9NUS5
Gene	AP5S1
Organism	Homo sapiens
Length	200 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (6)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.04
platelet component distribution width · score 0.04
mean corpuscular volume · score 0.04
platelet count · score 0.02
cardiovascular disease · score 0.00
hereditary spastic paraplegia · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NUS5-F1	alphafold	PREDICTED	80.43	—

Amino-acid sequence (200 residues)

MVHAFLIHTL RAPNTEDTGL CRVLYSCVFG AEKSPDDPRP HGAERDRLLR KEQILAVARQ VESMCRLQQQ ASGRPPMDLQ PQSSDEQVPL HEAPRGAFRL AAENPFQEPR TVVWLGVLSL GFALVLDAHE NLLLAEGTLR LLTRLLLDHL RLLAPSTSLL LRADRIEGIL TRFLPHGQLL FLNDQFVQGL EKEFSAAWPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards