About Protection of telomeres protein 1
Protection of telomeres protein 1 (POT1) is a protein
from Homo sapiens identified by UniProt accession
Q9NUX5, 634 residues long.
MolForge cross-references it against 0 known binders and
278 disease associations.
Target properties
| Protein name | Protection of telomeres protein 1 |
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| UniProt accession | Q9NUX5 |
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| Gene | POT1 |
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| Organism | Homo sapiens |
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| Length | 634 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (278)
Diseases linked to this target (Open Targets).
- tumor predisposition syndrome 3 · score 0.79
- telomere length · score 0.66
- cutaneous melanoma · score 0.64
- chronic lymphocytic leukemia · score 0.63
- central nervous system cancer · score 0.57
- hereditary neoplastic syndrome · score 0.57
- Inherited cancer-predisposing syndrome · score 0.57
- neurodegenerative disease · score 0.53
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8 · score 0.45
- mean corpuscular volume · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NUX5-F1 | alphafold | PREDICTED | 87.40 | — |
Amino-acid sequence (634 residues)
MSLVPATNYI YTPLNQLKGG TIVNVYGVVK FFKPPYLSKG TDYCSVVTIV DQTNVKLTCL LFSGNYEALP IIYKNGDIVR FHRLKIQVYK KETQGITSSG FASLTFEGTL GAPIIPRTSS KYFNFTTEDH KMVEALRVWA STHMSPSWTL LKLCDVQPMQ YFDLTCQLLG KAEVDGASFL LKVWDGTRTP FPSWRVLIQD LVLEGDLSHI HRLQNLTIDI LVYDNHVHVA RSLKVGSFLR IYSLHTKLQS MNSENQTMLS LEFHLHGGTS YGRGIRVLPE SNSDVDQLKK DLESANLTAN QHSDVICQSE PDDSFPSSGS VSLYEVERCQ QLSATILTDH QYLERTPLCA ILKQKAPQQY RIRAKLRSYK PRRLFQSVKL HCPKCHLLQE VPHEGDLDII FQDGATKTPD VKLQNTSLYD SKIWTTKNQK GRKVAVHFVK NNGILPLSNE CLLLIEGGTL SEICKLSNKF NSVIPVRSGH EDLELLDLSA PFLIQGTIHH YGCKQCSSLR SIQNLNSLVD KTSWIPSSVA EALGIVPLQY VFVMTFTLDD GTGVLEAYLM DSDKFFQIPA SEVLMDDDLQ KSVDMIMDMF CPPGIKIDAY PWLECFIKSY NVTNGTDNQI CYQIFDTTVA EDVI
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