Nucleotide triphosphate diphosphatase NUDT15 (NUDT15)

About Nucleotide triphosphate diphosphatase NUDT15

Nucleotide triphosphate diphosphatase NUDT15 (NUDT15) is a protein from Homo sapiens identified by UniProt accession Q9NV35, 164 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Nucleotide triphosphate diphosphatase NUDT15
UniProt accession	Q9NV35
Gene	NUDT15
Organism	Homo sapiens
Length	164 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

leukopenia · score 0.37
alopecia · score 0.26
red blood cell density measurement · score 0.24
mean corpuscular hemoglobin · score 0.16
mean corpuscular hemoglobin concentration · score 0.13
Leukopenia · score 0.11
serum metabolite measurement · score 0.11
QT interval · score 0.10
creatinine measurement · score 0.10
hip bone size · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NV35-F1	alphafold	PREDICTED	92.73	—

Amino-acid sequence (164 residues)

MTASAQPRGR RPGVGVGVVV TSCKHPRCVL LGKRKGSVGA GSFQLPGGHL EFGETWEECA QRETWEEAAL HLKNVHFASV VNSFIEKENY HYVTILMKGE VDVTHDSEPK NVEPEKNESW EWVPWEELPP LDQLFWGLRC LKEQGYDPFK EDLNHLVGYK GNHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards