MRG/MORF4L-binding protein (MRGBP)

About MRG/MORF4L-binding protein

MRG/MORF4L-binding protein (MRGBP) is a protein from Homo sapiens identified by UniProt accession Q9NV56, 204 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	MRG/MORF4L-binding protein
UniProt accession	Q9NV56
Gene	MRGBP
Organism	Homo sapiens
Length	204 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
lysosomal storage disease · score 0.30
cholelithiasis · score 0.14
creatinine measurement · score 0.10
neoplasm · score 0.09
cancer · score 0.08
hepatocellular carcinoma · score 0.06
PHF-tau measurement · score 0.04
PR interval · score 0.02
systolic blood pressure · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NV56-F1	alphafold	PREDICTED	65.77	—

Amino-acid sequence (204 residues)

MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN PERNFVLPEE IIQEVREGKV MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL GKASEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK RRRT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards