About Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2) is a protein
from Homo sapiens identified by UniProt accession
Q9NV79, 361 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 |
|---|
| UniProt accession | Q9NV79 |
|---|
| Gene | PCMTD2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 361 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (27)
Diseases linked to this target (Open Targets).
- tea consumption measurement · score 0.31
- coffee consumption measurement · score 0.28
- bitter beverage consumption measurement · score 0.22
- glomerular filtration rate · score 0.22
- bitter non-alcoholic beverage consumption measurement · score 0.21
- low density lipoprotein cholesterol measurement · score 0.21
- coffee consumption · score 0.20
- self reported educational attainment · score 0.03
- mathematical ability · score 0.03
- body height · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NV79-F1 | alphafold | PREDICTED | 82.92 | — |
Amino-acid sequence (361 residues)
MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA YKDLAWKHGN IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL ILGPFGVNHG VELHSDVIEY AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL LKVGGILVMP LEEKLTKITR TGPSAWETKK ILAVSFAPLI QPCHSESGKS RLVQLPPVAV RSLQDLARIA IRGTIKKIIH QETVSKNGNG LKNTPRFKRR RVRRRRMETI VFLDKEVFAS RISNPSDDNS CEDLEEERRE EEEKTPPETK PDPPVNFLRQ KVLSLPLPDP LKYYLLYYRE K
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