NEDD4 family-interacting protein 2 (NDFIP2)

About NEDD4 family-interacting protein 2

NEDD4 family-interacting protein 2 (NDFIP2) is a protein from Homo sapiens identified by UniProt accession Q9NV92, 336 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	NEDD4 family-interacting protein 2
UniProt accession	Q9NV92
Gene	NDFIP2
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

cortical surface area measurement · score 0.36
neuroimaging measurement · score 0.33
diverticular disease · score 0.33
brain volume measurement · score 0.31
brain measurement · score 0.30
smoking status measurement · score 0.30
cortical thickness · score 0.30
intraocular pressure measurement · score 0.26
smoking behavior · score 0.24
antisocial behaviour measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NV92-F1	alphafold	PREDICTED	55.75	—

Amino-acid sequence (336 residues)

MARRRSQRVC ASGPSMLNSA RGAPELLRGT ATNAEVSAAA AGATGSEELP PGDRGCRNGG GRGPAATTSS TGVAVGAEHG EDSLSRKPDP EPGRMDHHQP GTGRYQVLLN EEDNSESSAI EQPPTSNPAP QIVQAASSAP ALETDSSPPP YSSITVEVPT TSDTEVYGEF YPVPPPYSVA TSLPTYDEAE KAKAAAMAAA AAETSQRIQE EECPPRDDFS DADQLRVGND GIFMLAFFMA FIFNWLGFCL SFCITNTIAG RYGAICGFGL SLIKWILIVR FSDYFTGYFN GQYWLWWIFL VLGLLLFFRG FVNYLKVRNM SESMAAAHRT RYFFLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards