SET domain-containing protein 4 (SETD4)

About SET domain-containing protein 4

SET domain-containing protein 4 (SETD4) is a protein from Homo sapiens identified by UniProt accession Q9NVD3, 440 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	SET domain-containing protein 4
UniProt accession	Q9NVD3
Gene	SETD4
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
C-reactive protein measurement · score 0.40
IGF-1 measurement · score 0.34
blood protein measurement · score 0.29
Mitral valve prolapse · score 0.20
insulin like growth factor measurement · score 0.13
heel bone mineral density · score 0.07
alkaline phosphatase measurement · score 0.05
bone density · score 0.04
hyperinsulinism due to INSR deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NVD3-F1	alphafold	PREDICTED	93.08	—

Amino-acid sequence (440 residues)

MQKGKGRTSR IRRRKLCGSS ESRGVNESHK SEFIELRKWL KARKFQDSNL APACFPGTGR GLMSQTSLQE GQMIISLPES CLLTTDTVIR SYLGAYITKW KPPPSPLLAL CTFLVSEKHA GHRSLWKPYL EILPKAYTCP VCLEPEVVNL LPKSLKAKAE EQRAHVQEFF ASSRDFFSSL QPLFAEAVDS IFSYSALLWA WCTVNTRAVY LRPRQRECLS AEPDTCALAP YLDLLNHSPH VQVKAAFNEE THSYEIRTTS RWRKHEEVFI CYGPHDNQRL FLEYGFVSVH NPHACVYVSR EILVKYLPST DKQMDKKISI LKDHGYIENL TFGWDGPSWR LLTALKLLCL EAEKFTCWKK VLLGEVISDT NEKTSLDIAQ KICYYFIEET NAVLQKVSHM KDEKEALINQ LTLVESLWTE ELKILRASAE TLHSLQTAFT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards