About ATPase family AAA domain-containing protein 3A
ATPase family AAA domain-containing protein 3A (ATAD3A) is a protein
from Homo sapiens identified by UniProt accession
Q9NVI7, 586 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | ATPase family AAA domain-containing protein 3A |
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| UniProt accession | Q9NVI7 |
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| Gene | ATAD3A |
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| Organism | Homo sapiens |
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| Length | 586 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- Harel-Yoon syndrome · score 0.79
- pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome, neonatal lethal · score 0.77
- lactic acidosis · score 0.46
- Lactic acidosis · score 0.46
- genetic disorder · score 0.42
- isolated cerebellar hypoplasia/agenesis · score 0.34
- neurodegenerative disease · score 0.29
- Global developmental delay · score 0.19
- systemic scleroderma · score 0.19
- Dystonia · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NVI7-F1 | alphafold | PREDICTED | 81.82 | — |
Amino-acid sequence (586 residues)
MSWLFGINKG PKGEGAGPPP PLPPAQPGAE GGGDRGLGDR PAPKDKWSNF DPTGLERAAK AARELEHSRY AKDALNLAQM QEQTLQLEQQ SKLKEYEAAV EQLKSEQIRA QAEERRKTLS EETRQHQARA QYQDKLARQR YEDQLKQQQL LNEENLRKQE ESVQKQEAMR RATVEREMEL RHKNEMLRVE AEARARAKAE RENADIIREQ IRLKAAEHRQ TVLESIRTAG TLFGEGFRAF VTDWDKVTAT VAGLTLLAVG VYSAKNATLV AGRFIEARLG KPSLVRETSR ITVLEALRHP IQVSRRLLSR PQDALEGVVL SPSLEARVRD IAIATRNTKK NRSLYRNILM YGPPGTGKTL FAKKLALHSG MDYAIMTGGD VAPMGREGVT AMHKLFDWAN TSRRGLLLFV DEADAFLRKR ATEKISEDLR ATLNAFLYRT GQHSNKFMLV LASNQPEQFD WAINDRINEM VHFDLPGQEE RERLVRMYFD KYVLKPATEG KQRLKLAQFD YGRKCSEVAR LTEGMSGREI AQLAVSWQAT AYASEDGVLT EAMMDTRVQD AVQQHQQKMC WLKAEGPGRG DEPSPS
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