About Protein arginine N-methyltransferase 7
Protein arginine N-methyltransferase 7 (PRMT7) is a protein
from Homo sapiens identified by UniProt accession
Q9NVM4, 692 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Protein arginine N-methyltransferase 7 |
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| UniProt accession | Q9NVM4 |
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| Gene | PRMT7 |
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| Organism | Homo sapiens |
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| Length | 692 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (151)
Diseases linked to this target (Open Targets).
- short stature-brachydactyly-obesity-global developmental delay syndrome · score 0.77
- genetic disorder · score 0.49
- brachydactyly · score 0.43
- Skeletal dysplasia · score 0.43
- insulin resistance · score 0.43
- obesity · score 0.43
- Abnormal facial shape · score 0.43
- Abnormality of the dentition · score 0.43
- acanthosis nigricans · score 0.43
- Hepatic steatosis · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NVM4-F1 | alphafold | PREDICTED | 93.20 | — |
Amino-acid sequence (692 residues)
MKIFCSRANP TTGSVEWLEE DEHYDYHQEI ARSSYADMLH DKDRNVKYYQ GIRAAVSRVK DRGQKALVLD IGTGTGLLSM MAVTAGADFC YAIEVFKPMA DAAVKIVEKN GFSDKIKVIN KHSTEVTVGP EGDMPCRANI LVTELFDTEL IGEGALPSYE HAHRHLVEEN CEAVPHRATV YAQLVESGRM WSWNKLFPIH VQTSLGEQVI VPPVDVESCP GAPSVCDIQL NQVSPADFTV LSDVLPMFSI DFSKQVSSSA ACHSRRFEPL TSGRAQVVLS WWDIEMDPEG KIKCTMAPFW AHSDPEEMQW RDHWMQCVYF LPQEEPVVQG SALYLVAHHD DYCVWYSLQR TSPEKNERVR QMRPVCDCQA HLLWNRPRFG EINDQDRTDR YVQALRTVLK PDSVCLCVSD GSLLSVLAHH LGVEQVFTVE SSAASHKLLR KIFKANHLED KINIIEKRPE LLTNEDLQGR KVSLLLGEPF FTTSLLPWHN LYFWYVRTAV DQHLGPGAMV MPQAASLHAV VVEFRDLWRI RSPCGDCEGF DVHIMDDMIK RALDFRESRE AEPHPLWEYP CRSLSEPWQI LTFDFQQPVP LQPLCAEGTV ELRRPGQSHA AVLWMEYHLT PECTLSTGLL EPADPEGGCC WNPHCKQAVY FFSPAPDPRA LLGGPRTVSY AVEFHPDTGD IIMEFRHADT PD
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