About Kelch-like protein 11
Kelch-like protein 11 (KLHL11) is a protein
from Homo sapiens identified by UniProt accession
Q9NVR0, 708 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Kelch-like protein 11 |
|---|
| UniProt accession | Q9NVR0 |
|---|
| Gene | KLHL11 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 708 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- reticulocyte count · score 0.21
- reticulocyte measurement · score 0.20
- pancreatic adenocarcinoma · score 0.18
- allergic rhinitis · score 0.12
- mean corpuscular hemoglobin · score 0.09
- mean corpuscular volume · score 0.07
- mean corpuscular hemoglobin concentration · score 0.06
- Immature Reticulocyte Fraction Measurement · score 0.06
- blood protein measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NVR0-F1 | alphafold | PREDICTED | 81.38 | — |
Amino-acid sequence (708 residues)
MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP GPGISAMEAS GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF GGAGGREFRA HRSVLAAATE YFTPLLSGQF SESRSGRVEM RKWSSEPGPE PDTVEAVIEY MYTGRIRVST GSVHEVLELA DRFLLIRLKE FCGEFLKKKL HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE FYTLPFHLIR DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL LPRYGQNMDV IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH AVAVTESYVY VAGSMEPGFA KTVERYNPNL NTWEHVCSLM TRKHSFGLTE VKGKLYSIGG HGNFSPGFKD VTVYNPELDK WHNLESAPKI LRDVKALAIE DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL PLIDNYCFFQ MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP RCRATACHVR IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR VPSSQIEC
Explore Kelch-like protein 11 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets