About Zinc finger protein 358
Zinc finger protein 358 (ZNF358) is a protein
from Homo sapiens identified by UniProt accession
Q9NW07, 568 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Zinc finger protein 358 |
|---|
| UniProt accession | Q9NW07 |
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| Gene | ZNF358 |
|---|
| Organism | Homo sapiens |
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| Length | 568 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- electrocardiography · score 0.37
- left ventricular structural measurement · score 0.32
- PR interval · score 0.23
- hair colour measurement · score 0.22
- sitting height measurement · score 0.04
- eosinophil percentage of leukocytes · score 0.03
- eosinophil count · score 0.03
- lymphocyte count · score 0.03
- lymphocyte percentage of leukocytes · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NW07-F1 | alphafold | PREDICTED | 64.03 | — |
Amino-acid sequence (568 residues)
MRRSVLVRNP GHKGLRPVYE ELDSDSEDLD PNPEDLDPVS EDPEPDPEDL NTVPEDVDPS YEDLEPVSED LDPDAEAPGS EPQDPDPMSS SFDLDPDVIG PVPLILDPNS DTLSPGDPKV DPISSGLTAT PQVLATSPAV LPAPASPPRP FSCPDCGRAF RRSSGLSQHR RTHSGEKPYR CPDCGKSFSH GATLAQHRGI HTGARPYQCA ACGKAFGWRS TLLKHRSSHS GEKPHHCPVC GKAFGHGSLL AQHLRTHGGP RPHKCPVCAK GFGQGSALLK HLRTHTGERP YPCPQCGKAF GQSSALLQHQ RTHTAERPYR CPHCGKAFGQ SSNLQHHLRI HTGERPYACP HCSKAFGQSS ALLQHLHVHS GERPYRCQLC GKAFGQASSL TKHKRVHEGA AAAAAAAAAA AAAAAAGLGL GPGLSPASMM RPGQVSLLGP DAVSVLGSGL GLSPGTSSGR NPDPGSGPGT LPDPSSKPLP GSRSTPSPTP VESSDPKAGH DAGPDLVPSP DLDPVPSPDP DPVPSPDPNP VSCPDPCSPT RGTVSPALPT GESPEWVQEQ GALLGPDG
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