Pre-mRNA-splicing factor RBM22 (RBM22)

About Pre-mRNA-splicing factor RBM22

Pre-mRNA-splicing factor RBM22 (RBM22) is a protein from Homo sapiens identified by UniProt accession Q9NW64, 420 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	Pre-mRNA-splicing factor RBM22
UniProt accession	Q9NW64
Gene	RBM22
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
glioblastoma · score 0.07
Syndactyly type 2 · score 0.06
syndactyly type 4 · score 0.06
Split hand-split foot malformation · score 0.05
syndactyly type 5 · score 0.05
mesoaxial synostotic syndactyly with phalangeal reduction · score 0.05
synpolydactyly type 1 · score 0.05
syndactyly type 1 · score 0.05
polydactyly of a triphalangeal thumb · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NW64-F1	alphafold	PREDICTED	76.10	—

Amino-acid sequence (420 residues)

MATSLGSNTY NRQNWEDADF PILCQTCLGE NPYIRMTKEK YGKECKICAR PFTVFRWCPG VRMRFKKTEV CQTCSKLKNV CQTCLLDLEY GLPIQVRDAG LSFKDDMPKS DVNKEYYTQN MEREISNSDG TRPVGMLGKA TSTSDMLLKL ARTTPYYKRN RPHICSFWVK GECKRGEECP YRHEKPTDPD DPLADQNIKD RYYGINDPVA DKLLKRASTM PRLDPPEDKT ITTLYVGGLG DTITETDLRN HFYQFGEIRT ITVVQRQQCA FIQFATRQAA EVAAEKSFNK LIVNGRRLNV KWGRSQAARG KEKEKDGTTD SGIKLEPVPG LPGALPPPPA AEEEASANYF NLPPSGPPAV VNIALPPPPG IAPPPPPGFG PHMFHPMGPP PPFMRAPGPI HYPSQDPQRM GAHAGKHSSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards