About Transmembrane protein 45A
Transmembrane protein 45A (TMEM45A) is a protein
from Homo sapiens identified by UniProt accession
Q9NWC5, 275 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Transmembrane protein 45A |
|---|
| UniProt accession | Q9NWC5 |
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| Gene | TMEM45A |
|---|
| Organism | Homo sapiens |
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| Length | 275 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- glucose measurement · score 0.28
- nonpapillary renal cell carcinoma · score 0.08
- cancer · score 0.05
- clear cell renal carcinoma · score 0.05
- refractive error · score 0.04
- hemoglobin H disease · score 0.03
- dominant beta-thalassemia · score 0.03
- glycoprotein storage disease · score 0.03
- head and neck squamous cell carcinoma · score 0.03
- breast cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NWC5-F1 | alphafold | PREDICTED | 91.96 | — |
Amino-acid sequence (275 residues)
MGNFRGHALP GTFFFIIGLW WCTKSILKYI CKKQKRTCYL GSKTLFYRLE ILEGITIVGM ALTGMAGEQF IPGGPHLMLY DYKQGHWNQL LGWHHFTMYF FFGLLGVADI LCFTISSLPV SLTKLMLSNA LFVEAFIFYN HTHGREMLDI FVHQLLVLVV FLTGLVAFLE FLVRNNVLLE LLRSSLILLQ GSWFFQIGFV LYPPSGGPAW DLMDHENILF LTICFCWHYA VTIVIVGMNY AFITWLVKSR LKRLCSSEVG LLKNAEREQE SEEEM
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