Transmembrane protein 248 (TMEM248)

About Transmembrane protein 248

Transmembrane protein 248 (TMEM248) is a protein from Homo sapiens identified by UniProt accession Q9NWD8, 314 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Transmembrane protein 248
UniProt accession	Q9NWD8
Gene	TMEM248
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

central corneal thickness · score 0.38
corneal topography · score 0.29
monocyte percentage of leukocytes · score 0.14
Parkinson disease · score 0.11
gait measurement · score 0.08
sitting height measurement · score 0.06
aspartate aminotransferase measurement · score 0.06
leukocyte count · score 0.06
neutrophil count · score 0.05
cholesteryl ester storage disease · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NWD8-F1	alphafold	PREDICTED	72.02	—

Amino-acid sequence (314 residues)

MFSINPLENL KVYISSRPPL VVFMISVSAM AIAFLTLGYF FKIKEIKSPE MAEDWNTFLL RFNDLDLCVS ENETLKHLTN DTTTPESTMT SGQARASTQS PQALEDSGPV NISVSITLTL DPLKPFGGYS RNVTHLYSTI LGHQIGLSGR EAHEEINITF TLPTAWSSDD CALHGHCEQV VFTACMTLTA SPGVFPVTVQ PPHCVPDTYS NATLWYKIFT TARDANTKYA QDYNPFWCYK GAIGKVYHAL NPKLTVIVPD DDRSLINLHL MHTSYFLFVM VITMFCYAVI KGRPSKLRQS NPEFCPEKVA LAEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards