About Spermatogenesis-associated protein 6
Spermatogenesis-associated protein 6 (SPATA6) is a protein
from Homo sapiens identified by UniProt accession
Q9NWH7, 488 residues long.
MolForge cross-references it against 0 known binders and
161 disease associations.
Target properties
| Protein name | Spermatogenesis-associated protein 6 |
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| UniProt accession | Q9NWH7 |
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| Gene | SPATA6 |
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| Organism | Homo sapiens |
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| Length | 488 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (161)
Diseases linked to this target (Open Targets).
- urinary metabolite measurement · score 0.32
- azoospermia · score 0.10
- urate measurement · score 0.10
- systolic blood pressure · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 65 · score 0.08
- spermatogenic failure 56 · score 0.08
- spermatogenic failure, X-linked, 3 · score 0.08
- spermatogenic failure 72 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NWH7-F1 | alphafold | PREDICTED | 65.18 | — |
Amino-acid sequence (488 residues)
MPKVKALQCA LALEISSVTC PGVVLKDKED IYLSICVFGQ YKKTQCVPAT FPLVFNARMV FEKVFPDAVD PGDVVTQLEY DTAVFELIQL VPPVGETLST YDENTRDFMF PGPNQMSGHH DSNRQVTMRR ISGLRGNAPR LEFSTTSVIT ECLISSRKCH TQDKFIYHLA PVEKSHGRLQ NRTSRSQKKK SKSPERSKYC INAKNYEQPT ISSKSHSPSP YTKRRMCELS EDTRRRLAHL NLGPYEFKKE TDKPPFVIRH VDPPSPRADT LLGSSGRDCE RDGWSRVHND HSHLGCCRPK DYKVIRTPHG RDFDDSLEKC EEYLSPRSCS KPRHSARTLL VHSAPSTMPK HSPSPVLNRA SLRERFHSDW CSPSNCDEIH DRVKNVLKSH QAHQRHLYDE RDLEKDDELE LKRSLLCRDS AYDSDPEYSS CQQPRGTFHL DDGEYWSNRA ASYKGKSHRP IFENSMDKMY RNLYKKACSS ASHTQESF
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