About SAFB-like transcription modulator
SAFB-like transcription modulator (SLTM) is a protein
from Homo sapiens identified by UniProt accession
Q9NWH9, 1034 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | SAFB-like transcription modulator |
|---|
| UniProt accession | Q9NWH9 |
|---|
| Gene | SLTM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1034 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (16)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Abnormality of the skeletal system · score 0.28
- Jeune syndrome · score 0.26
- schizophrenia · score 0.21
- body mass index · score 0.15
- appendicular lean mass · score 0.09
- apolipoprotein A 1 measurement · score 0.08
- cigarettes per day measurement · score 0.04
- drug use measurement · score 0.04
- chronic kidney disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NWH9-F1 | alphafold | PREDICTED | 51.71 | — |
Amino-acid sequence (1034 residues)
MAAATGAVAA SAASGQAEGK KITDLRVIDL KSELKRRNLD ITGVKTVLIS RLKQAIEEEG GDPDNIELTV STDTPNKKPT KGKGKKHEAD ELSGDASVED DAFIKDCELE NQEAHEQDGN DELKDSEEFG ENEEENVHSK ELLSAEENKR AHELIEAEGI EDIEKEDIES QEIEAQEGED DTFLTAQDGE EEENEKDIAG SGDGTQEVSK PLPSEGSLAE ADHTAHEEME AHTTVKEAED DNISVTIQAE DAITLDFDGD DLLETGKNVK ITDSEASKPK DGQDAIAQSP EKESKDYEMN ANHKDGKKED CVKGDPVEKE ARESSKKAES GDKEKDTLKK GPSSTGASGQ AKSSSKESKD SKTSSKDDKG STSSTSGSSG SSTKNIWVSG LSSNTKAADL KNLFGKYGKV LSAKVVTNAR SPGAKCYGIV TMSSSTEVSR CIAHLHRTEL HGQLISVEKV KGDPSKKEMK KENDEKSSSR SSGDKKNTSD RSSKTQASVK KEEKRSSEKS EKKESKDTKK IEGKDEKNDN GASGQTSESI KKSEEKKRIS SKSPGHMVIL DQTKGDHCRP SRRGRYEKIH GRSKEKERAS LDKKRDKDYR RKEILPFEKM KEQRLREHLV RFERLRRAME LRRRREIAER ERRERERIRI IREREERERL QRERERLEIE RQKLERERME RERLERERIR IEQERRKEAE RIAREREELR RQQQQLRYEQ EKRNSLKRPR DVDHRRDDPY WSENKKLSLD TDARFGHGSD YSRQQNRFND FDHRERGRFP ESSAVQSSSF ERRDRFVGQS EGKKARPTAR REDPSFERYP KNFSDSRRNE PPPPRNELRE SDRREVRGER DERRTVIIHD RPDITHPRHP REAGPNPSRP TSWKSEGSMS TDKRETRVER PERSGREVSG HSVRGAPPGN RSSASGYGSR EGDRGVITDR GGGSQHYPEE RHVVERHGRD TSGPRKEWHG PPSQGPSYHD TRRMGDGRAG AGMITQHSSN ASPINRIVQI SGNSMPRGSG SGFKPFKGGP PRRF
Explore SAFB-like transcription modulator with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets