PIH1 domain-containing protein 1 (PIH1D1)

About PIH1 domain-containing protein 1

PIH1 domain-containing protein 1 (PIH1D1) is a protein from Homo sapiens identified by UniProt accession Q9NWS0, 290 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	PIH1 domain-containing protein 1
UniProt accession	Q9NWS0
Gene	PIH1D1
Organism	Homo sapiens
Length	290 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
total cholesterol measurement · score 0.16
low density lipoprotein cholesterol measurement · score 0.08
red blood cell density measurement · score 0.04
blood protein measurement · score 0.03
brain cancer · score 0.01
diffuse large B-cell lymphoma · score 0.01
exfoliation syndrome · score 0.00
glaucoma · score 0.00
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NWS0-F1	alphafold	PREDICTED	78.78	—

Amino-acid sequence (290 residues)

MANPKLLGMG LSEAEAIGAD SARFEELLLQ ASKELQQAQT TRPESTQIQP QPGFCIKTNS SEGKVFINIC HSPSIPPPAD VTEEELLQML EEDQAGFRIP MSLGEPHAEL DAKGQGCTAY DVAVNSDFYR RMQNSDFLRE LVITIAREGL EDKYNLQLNP EWRMMKNRPF MGSISQQNIR SEQRPRIQEL GDLYTPAPGR AESGPEKPHL NLWLEAPDLL LAEVDLPKLD GALGLSLEIG ENRLVMGGPQ QLYHLDAYIP LQINSHESKA AFHRKRKQLM VAMPLLPVPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards