About Required for meiotic nuclear division protein 1 homolog
Required for meiotic nuclear division protein 1 homolog (RMND1) is a protein
from Homo sapiens identified by UniProt accession
Q9NWS8, 449 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Required for meiotic nuclear division protein 1 homolog |
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| UniProt accession | Q9NWS8 |
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| Gene | RMND1 |
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| Organism | Homo sapiens |
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| Length | 449 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (73)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation defect type 11 · score 0.80
- mitochondrial disease · score 0.61
- genetic disorder · score 0.48
- nephronophthisis · score 0.42
- neurodegenerative disease · score 0.38
- Perrault syndrome 2 · score 0.37
- Perrault syndrome 1 · score 0.37
- mitochondrial oxidative phosphorylation disorder · score 0.34
- lean body mass · score 0.28
- Abnormality of the nervous system · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NWS8-F1 | alphafold | PREDICTED | 69.95 | — |
Amino-acid sequence (449 residues)
MPATLLRAVA RSHHILSKAH QCRRIGHLML KPLKEFENTT CSTLTIRQSL DLFLPDKTAS GLNKSQILEM NQKKSDTSML SPLNAARCQD EKAHLPTMKS FGTHRRVTHK PNLLGSKWFI KILKRHFSSV STETFVPKQD FPQVKRPLKA SRTRQPSRTN LPVLSVNEDL MHCTAFATAD EYHLGNLSQD LASHGYVEVT SLPRDAANIL VMGVENSAKE GDPGTIFFFR EGAAVFWNVK DKTMKHVMKV LEKHEIQPYE IALVHWENEE LNYIKIEGQS KLHRGEIKLN SELDLDDAIL EKFAFSNALC LSVKLAIWEA SLDKFIESIQ SIPEALKAGK KVKLSHEEVM QKIGELFALR HRINLSSDFL ITPDFYWDRE NLEGLYDKTC QFLSIGRRVK VMNEKLQHCM ELTDLMRNHL NEKRALRLEW MIVILITIEV MFELGRVFF
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