Zinc finger protein 446 (ZNF446)

About Zinc finger protein 446

Zinc finger protein 446 (ZNF446) is a protein from Homo sapiens identified by UniProt accession Q9NWS9, 450 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Zinc finger protein 446
UniProt accession	Q9NWS9
Gene	ZNF446
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

Short stature · score 0.37
pathological myopia · score 0.11
Myopia · score 0.11
age at menarche · score 0.09
puberty onset measurement · score 0.07
cognitive function measurement · score 0.06
mean corpuscular volume · score 0.04
intelligence · score 0.03
heel bone mineral density · score 0.03
mean platelet volume · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NWS9-F1	alphafold	PREDICTED	57.58	—

Amino-acid sequence (450 residues)

MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GNHGHQEPAS TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC GCSFSWKSQL VIHRKSHTGQ RRHFCSDCGR AFDWKSQLVI HRKGHRPEVP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards