About COMM domain-containing protein 8
COMM domain-containing protein 8 (COMMD8) is a protein
from Homo sapiens identified by UniProt accession
Q9NX08, 183 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | COMM domain-containing protein 8 |
|---|
| UniProt accession | Q9NX08 |
|---|
| Gene | COMMD8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 183 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- non-small cell lung carcinoma · score 0.05
- sleep apnea · score 0.05
- sphingolipid measurement · score 0.05
- risk-taking behaviour · score 0.04
- serum metabolite measurement · score 0.03
- urate measurement · score 0.02
- heel bone mineral density · score 0.02
- hepatocellular carcinoma · score 0.02
- bacteriemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NX08-F1 | alphafold | PREDICTED | 87.17 | — |
Amino-acid sequence (183 residues)
MEPEEGTPLW RLQKLPAELG PQLLHKIIDG ICGRAYPVYQ DYHTVWESEE WMHVLEDIAK FFKAIVGKNL PDEEIFQQLN QLNSLHQETI MKCVKSRKDE IKQALSREIV AISSAQLQDF DWQVKLALSS DKIAALRMPL LSLHLDVKEN GEVKPYSIEM SREELQNLIQ SLEAANKVVL QLK
Explore COMM domain-containing protein 8 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets