About CKLF-like MARVEL transmembrane domain-containing protein 6
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is a protein
from Homo sapiens identified by UniProt accession
Q9NX76, 183 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | CKLF-like MARVEL transmembrane domain-containing protein 6 |
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| UniProt accession | Q9NX76 |
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| Gene | CMTM6 |
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| Organism | Homo sapiens |
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| Length | 183 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (105)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.45
- total cholesterol measurement · score 0.44
- apolipoprotein B measurement · score 0.39
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.11
- glioblastoma multiforme · score 0.09
- cancer · score 0.09
- breast cancer · score 0.08
- pancreatic adenocarcinoma · score 0.08
- lung adenocarcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NX76-F1 | alphafold | PREDICTED | 77.30 | — |
Amino-acid sequence (183 residues)
MENGAVYSPT TEEDPGPARG PRSGLAAYFF MGRLPLLRRV LKGLQLLLSL LAFICEEVVS QCTLCGGLYF FEFVSCSAFL LSLLILIVYC TPFYERVDTT KVKSSDFYIT LGTGCVFLLA SIIFVSTHDR TSAEIAAIVF GFIASFMFLL DFITMLYEKR QESQLRKPEN TTRAEALTEP LNA
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