About THUMP domain-containing protein 1
THUMP domain-containing protein 1 (THUMPD1) is a protein
from Homo sapiens identified by UniProt accession
Q9NXG2, 353 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | THUMP domain-containing protein 1 |
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| UniProt accession | Q9NXG2 |
|---|
| Gene | THUMPD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 353 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with speech delay and variable ocular anomalies · score 0.63
- Neurodevelopmental disorder · score 0.52
- genetic disorder · score 0.34
- neurodegenerative disease · score 0.30
- body height · score 0.29
- mean corpuscular volume · score 0.18
- eosinophil count · score 0.15
- appendicular lean mass · score 0.13
- sitting height measurement · score 0.12
- erythrocyte count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NXG2-F1 | alphafold | PREDICTED | 73.84 | — |
Amino-acid sequence (353 residues)
MAAPAQQTTQ PGGGKRKGKA QYVLAKRARR CDAGGPRQLE PGLQGILITC NMNERKCVEE AYSLLNEYGD DMYGPEKFTD KDQQPSGSEG EDDDAEAALK KEVGDIKAST EMRLRRFQSV ESGANNVVFI RTLGIEPEKL VHHILQDMYK TKKKKTRVIL RMLPISGTCK AFLEDMKKYA ETFLEPWFKA PNKGTFQIVY KSRNNSHVNR EEVIRELAGI VCTLNSENKV DLTNPQYTVV VEIIKAVCCL SVVKDYMLFR KYNLQEVVKS PKDPSQLNSK QGNGKEAKLE SADKSDQNNT AEGKNNQQVP ENTEELGQTK PTSNPQVVNE GGAKPELASQ ATEGSKSNEN DFS
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