About Probable ATP-dependent RNA helicase DDX43
Probable ATP-dependent RNA helicase DDX43 (DDX43) is a protein
from Homo sapiens identified by UniProt accession
Q9NXZ2, 648 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX43 |
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| UniProt accession | Q9NXZ2 |
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| Gene | DDX43 |
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| Organism | Homo sapiens |
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| Length | 648 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.08
- breast cancer · score 0.08
- chronic myelogenous leukemia · score 0.05
- melanoma · score 0.03
- acute myeloid leukemia · score 0.03
- cancer · score 0.02
- cystic fibrosis · score 0.02
- triple-negative breast cancer · score 0.01
- Uveal melanoma · score 0.01
- Down syndrome · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NXZ2-F1 | alphafold | PREDICTED | 79.70 | — |
Amino-acid sequence (648 residues)
MSHHGGAPKA STWVVASRRS STVSRAPERR PAEELNRTGP EGYSVGRGGR WRGTSRPPEA VAAGHEELPL CFALKSHFVG AVIGRGGSKI KNIQSTTNTT IQIIQEQPES LVKIFGSKAM QTKAKAVIDN FVKKLEENYN SECGIDTAFQ PSVGKDGSTD NNVVAGDRPL IDWDQIREEG LKWQKTKWAD LPPIKKNFYK ESTATSAMSK VEADSWRKEN FNITWDDLKD GEKRPIPNPT CTFDDAFQCY PEVMENIKKA GFQKPTPIQS QAWPIVLQGI DLIGVAQTGT GKTLCYLMPG FIHLVLQPSL KGQRNRPGML VLTPTRELAL QVEGECCKYS YKGLRSVCVY GGGNRDEQIE ELKKGVDIII ATPGRLNDLQ MSNFVNLKNI TYLVLDEADK MLDMGFEPQI MKILLDVRPD RQTVMTSATW PHSVHRLAQS YLKEPMIVYV GTLDLVAVSS VKQNIIVTTE EEKWSHMQTF LQSMSSTDKV IVFVSRKAVA DHLSSDLILG NISVESLHGD REQRDREKAL ENFKTGKVRI LIATDLASRG LDVHDVTHVY NFDFPRNIEE YVHRIGRTGR AGRTGVSITT LTRNDWRVAS ELINILERAN QSIPEELVSM AERFKAHQQK REMERKMERP QGRPKKFH
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