Very-long-chain enoyl-CoA reductase (TECR)

About Very-long-chain enoyl-CoA reductase

Very-long-chain enoyl-CoA reductase (TECR) is a protein from Homo sapiens identified by UniProt accession Q9NZ01, 308 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Very-long-chain enoyl-CoA reductase
UniProt accession	Q9NZ01
Gene	TECR
Organism	Homo sapiens
Length	308 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
autosomal recessive non-syndromic intellectual disability · score 0.47
risk-taking behaviour · score 0.19
bone density · score 0.09
urate measurement · score 0.09
protein measurement · score 0.09
annular pancreas · score 0.06
hypertriglyceridemia 2 · score 0.06
cholesterol-ester transfer protein deficiency · score 0.05
Combined hyperlipidemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NZ01-F1	alphafold	PREDICTED	94.37	—

Amino-acid sequence (308 residues)

MKHYEVEILD AKTREKLCFL DKVEPHATIA EIKNLFTKTH PQWYPARQSL RLDPKGKSLK DEDVLQKLPV GTTATLYFRD LGAQISWVTV FLTEYAGPLF IYLLFYFRVP FIYGHKYDFT SSRHTVVHLA CICHSFHYIK RLLETLFVHR FSHGTMPLRN IFKNCTYYWG FAAWMAYYIN HPLYTPPTYG AQQVKLALAI FVICQLGNFS IHMALRDLRP AGSKTRKIPY PTKNPFTWLF LLVSCPNYTY EVGSWIGFAI MTQCLPVALF SLVGFTQMTI WAKGKHRSYL KEFRDYPPLR MPIIPFLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards