Ubiquitin-associated protein 1 (UBAP1)

About Ubiquitin-associated protein 1

Ubiquitin-associated protein 1 (UBAP1) is a protein from Homo sapiens identified by UniProt accession Q9NZ09, 502 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Ubiquitin-associated protein 1
UniProt accession	Q9NZ09
Gene	UBAP1
Organism	Homo sapiens
Length	502 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (124)

Diseases linked to this target (Open Targets).

spastic paraplegia 80, autosomal dominant · score 0.69
neurodegenerative disease · score 0.53
HIV infection · score 0.53
hereditary spastic paraplegia · score 0.52
viral disease · score 0.46
Autosomal dominant spastic paraplegia type 12 · score 0.38
Red cell distribution width · score 0.24
plasminogen activator inhibitor 1 measurement · score 0.22
genetic disorder · score 0.19
serum urea measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NZ09-F1	alphafold	PREDICTED	62.50	—

Amino-acid sequence (502 residues)

MASKKLGADF HGTFSYLDDV PFKTGDKFKT PAKVGLPIGF SLPDCLQVVR EVQYDFSLEK KTIEWAEEIK KIEEAEREAE CKIAEAEAKV NSKSGPEGDS KMSFSKTHST ATMPPPINPI LASLQHNSIL TPTRVSSSAT KQKVLSPPHI KADFNLADFE CEEDPFDNLE LKTIDEKEEL RNILVGTTGP IMAQLLDNNL PRGGSGSVLQ DEEVLASLER ATLDFKPLHK PNGFITLPQL GNCEKMSLSS KVSLPPIPAV SNIKSLSFPK LDSDDSNQKT AKLASTFHST SCLRNGTFQN SLKPSTQSSA SELNGHHTLG LSALNLDSGT EMPALTSSQM PSLSVLSVCT EESSPPNTGP TVTPPNFSVS QVPNMPSCPQ AYSELQMLSP SERQCVETVV NMGYSYECVL RAMKKKGENI EQILDYLFAH GQLCEKGFDP LLVEEALEMH QCSEEKMMEF LQLMSKFKEM GFELKDIKEV LLLHNNDQDN ALEDLMARAG AS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards