CDGSH iron-sulfur domain-containing protein 1 (CISD1)

About CDGSH iron-sulfur domain-containing protein 1

CDGSH iron-sulfur domain-containing protein 1 (CISD1) is a protein from Homo sapiens identified by UniProt accession Q9NZ45, 108 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	CDGSH iron-sulfur domain-containing protein 1
UniProt accession	Q9NZ45
Gene	CISD1
Organism	Homo sapiens
Length	108 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (10)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (88)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
monocyte count · score 0.29
inflammatory bowel disease · score 0.14
monocyte percentage of leukocytes · score 0.13
platelet component distribution width · score 0.13
Cleft palate · score 0.12
cleft lip · score 0.12
sex interaction measurement · score 0.12
Crohn's disease · score 0.11
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NZ45-F1	alphafold	PREDICTED	91.18	—

Amino-acid sequence (108 residues)

MSLTSSSSVR VEWIAAVTIA AGTAAIGYLA YKRFYVKDHR NKAMINLHIQ KDNPKIVHAF DMEDLGDKAV YCRCWRSKKF PFCDGAHTKH NEETGDNVGP LIIKKKET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards