About ADP-ribosylation factor-binding protein GGA3
ADP-ribosylation factor-binding protein GGA3 (GGA3) is a protein
from Homo sapiens identified by UniProt accession
Q9NZ52, 723 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | ADP-ribosylation factor-binding protein GGA3 |
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| UniProt accession | Q9NZ52 |
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| Gene | GGA3 |
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| Organism | Homo sapiens |
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| Length | 723 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- lung adenocarcinoma · score 0.23
- testosterone measurement · score 0.18
- breast adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.17
- waist-hip ratio · score 0.09
- non-small cell lung carcinoma · score 0.07
- systemic scleroderma · score 0.07
- triglyceride measurement · score 0.06
- sex hormone-binding globulin measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NZ52-F1 | alphafold | PREDICTED | 69.72 | — |
Amino-acid sequence (723 residues)
MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW EALQALTVLE ACMKNCGRRF HNEVGKFRFL NELIKVVSPK YLGDRVSEKV KTKVIELLYS WTMALPEEAK IKDAYHMLKR QGIVQSDPPI PVDRTLIPSP PPRPKNPVFD DEEKSKLLAK LLKSKNPDDL QEANKLIKSM VKEDEARIQK VTKRLHTLEE VNNNVRLLSE MLLHYSQEDS SDGDRELMKE LFDQCENKRR TLFKLASETE DNDNSLGDIL QASDNLSRVI NSYKTIIEGQ VINGEVATLT LPDSEGNSQC SNQGTLIDLA ELDTTNSLSS VLAPAPTPPS SGIPILPPPP QASGPPRSRS SSQAEATLGP SSTSNALSWL DEELLCLGLA DPAPNVPPKE SAGNSQWHLL QREQSDLDFF SPRPGTAACG ASDAPLLQPS APSSSSSQAP LPPPFPAPVV PASVPAPSAG SSLFSTGVAP ALAPKVEPAV PGHHGLALGN SALHHLDALD QLLEEAKVTS GLVKPTTSPL IPTTTPARPL LPFSTGPGSP LFQPLSFQSQ GSPPKGPELS LASIHVPLES IKPSSALPVT AYDKNGFRIL FHFAKECPPG RPDVLVVVVS MLNTAPLPVK SIVLQAAVPK SMKVKLQPPS GTELSPFSPI QPPAAITQVM LLANPLKEKV RLRYKLTFAL GEQLSTEVGE VDQFPPVEQW GNL
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