Large ribosomal subunit protein uL15m (MRPL15)

About Large ribosomal subunit protein uL15m

Large ribosomal subunit protein uL15m (MRPL15) is a protein from Homo sapiens identified by UniProt accession Q9P015, 296 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Large ribosomal subunit protein uL15m
UniProt accession	Q9P015
Gene	MRPL15
Organism	Homo sapiens
Length	296 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
viral load · score 0.13
drug use measurement · score 0.10
pulmonary arterial hypertension · score 0.05
platelet component distribution width · score 0.04
systemic juvenile idiopathic arthritis · score 0.01
ovarian carcinoma · score 0.01
major depressive disorder · score 0.01
Alzheimer disease · score 0.01
invasive breast ductal carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P015-F1	alphafold	PREDICTED	91.01	—

Amino-acid sequence (296 residues)

MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSFR RQYKPLSLNR LQYLIDLGRV DPSQPIDLTQ LVNGRGVTIQ PLKRDYGVQL VEEGADTFTA KVNIEVQLAS ELAIAAIEKN GGVVTTAFYD PRSLDIVCKP VPFFLRGQPI PKRMLPPEEL VPYYTDAKNR GYLADPAKFP EARLELARKY GYILPDITKD ELFKMLCTRK DPRQIFFGLA PGWVVNMADK KILKPTDENL LKYYTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards