About Thyroid transcription factor 1-associated protein 26
Thyroid transcription factor 1-associated protein 26 (CCDC59) is a protein
from Homo sapiens identified by UniProt accession
Q9P031, 241 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Thyroid transcription factor 1-associated protein 26 |
|---|
| UniProt accession | Q9P031 |
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| Gene | CCDC59 |
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| Organism | Homo sapiens |
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| Length | 241 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.20
- body mass index · score 0.18
- grey matter volume measurement · score 0.15
- protein measurement · score 0.14
- adolescent idiopathic scoliosis · score 0.11
- diet measurement · score 0.10
- early-onset non-syndromic cataract · score 0.07
- Cataract-microcornea syndrome · score 0.06
- Blackfan-Diamond anemia · score 0.06
- Total congenital cataract · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P031-F1 | alphafold | PREDICTED | 73.28 | — |
Amino-acid sequence (241 residues)
MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR EGQGFAFRRK LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE EERHRKQARK VDHPLSEQVH QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ AKRAAKKQEF ERRKQEREEA QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK C
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