NADH dehydrogenase [ubiquinone] 1 alpha subcomplex…

About NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4) is a protein from Homo sapiens identified by UniProt accession Q9P032, 175 residues long. MolForge cross-references it against 0 known binders and 225 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
UniProt accession	Q9P032
Gene	NDUFAF4
Organism	Homo sapiens
Length	175 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (225)

Diseases linked to this target (Open Targets).

mitochondrial complex I deficiency · score 0.70
type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55
insulin resistance · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P032-F1	alphafold	PREDICTED	83.04	—

Amino-acid sequence (175 residues)

MGALVIRGIR NFNLENRAER EISKMKPSVA PRHPSTNSLL REQISLYPEV KGEIARKDEK LLSFLKDVYV DSKDPVSSLQ VKAAETCQEP KEFRLPKDHH FDMINIKSIP KGKISIVEAL TLLNNHKLFP ETWTAEKIMQ EYQLEQKDVN SLLKYFVTFE VEIFPPEDKK AIRSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4)