About SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) is a protein
from Homo sapiens identified by UniProt accession
Q9P0W2, 317 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related |
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| UniProt accession | Q9P0W2 |
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| Gene | HMG20B |
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| Organism | Homo sapiens |
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| Length | 317 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- body height · score 0.21
- lean body mass · score 0.20
- glioblastoma multiforme · score 0.15
- body weights and measures · score 0.15
- appendicular lean mass · score 0.14
- whole body water mass · score 0.13
- anthropometric measurement · score 0.13
- base metabolic rate measurement · score 0.11
- skin pigmentation measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P0W2-F1 | alphafold | PREDICTED | 77.91 | — |
Amino-acid sequence (317 residues)
MSHGPKQPGA AAAPAGGKAP GQHGGFVVTV KQERGEGPRA GEKGSHEEEP VKKRGWPKGK KRKKILPNGP KAPVTGYVRF LNERREQIRT RHPDLPFPEI TKMLGAEWSK LQPTEKQRYL DEAEREKQQY MKELRAYQQS EAYKMCTEKI QEKKIKKEDS SSGLMNTLLN GHKGGDCDGF STFDVPIFTE EFLDQNKARE AELRRLRKMN VAFEEQNAVL QRHTQSMSSA RERLEQELAL EERRTLALQQ QLQAVRQALT ASFASLPVPG TGETPTLGTL DFYMARLHGA IERDPAQHEK LIVRIKEILA QVASEHL
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